Journal article
Childhood trauma and treatment outcomes during mood-stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder
AL Wrobel, O Köhler-Forsberg, LG Sylvia, SE Russell, OM Dean, SM Cotton, M Thase, JR Calabrese, T Deckersbach, M Tohen, CL Bowden, MG McInnis, JH Kocsis, ES Friedman, TA Ketter, RC Shelton, MJ Ostacher, DV Iosifescu, M Berk, A Turner Show all
Acta Psychiatrica Scandinavica | WILEY | Published : 2022
DOI: 10.1111/acps.13420
Abstract
Background: Childhood trauma affects the course of mood disorders. Researchers are now considering childhood trauma as an influential factor in the treatment of mood disorders. However, the role of childhood trauma in the treatment of bipolar disorder remains understudied. Methods: The effect of childhood trauma on treatment outcomes was evaluated among participants randomised to treatment with lithium or quetiapine in the Clinical and Health Outcomes Initiatives in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE) study by clinician assessment. Mixed effects linear regression models were used to analyse rates of improvement in symptom severity (assessed with the Bipolar Invent..
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Awarded by J. Willard and Alice S. Marriott Foundation
Funding Acknowledgements
ALW is supported by a Deakin University Centre of Research Excellence in Psychiatric Treatment Postgraduate Research Scholarship. SER is supported by an Australian Government Research Training Program Scholarship. OMD is supported by a NHMRC R.D. Wright Biomedical Career Development Fellowship (APP1145634). SMC is supported by a NHMRC Senior Research Fellowship (APP1136344). MT is supported by the Atlas Foundation. MGM is supported by the Heinz C Prechter Bipolar Research Program and the Richard Tam Foundation. MB is supported by a NHMRC Senior Principal Research Fellowship (APP1156072). The Bipolar CHOICE trial was funded by the Agency for Healthcare Research and Quality (AHRQ): 1R01HS019371-01.